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Lipoprotein Fractionation Testing for Women's Heart Health
Advanced cholesterol particle testing, plus the inflammation and genetic markers that complete the picture.
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Nine panel tiers from $150.36 to $1,290.36 with the 20% promotion (list prices $187.95–$1,612.95 at time of writing).
At a glance
Lipoprotein fractionation testing measures the subclasses of cholesterol-carrying particles in your blood, detail a standard lipid panel does not show, alongside inflammation and clotting markers such as hs-CRP and fibrinogen activity, and the ApoE genotype. It is built for women who want a deeper set of markers associated with cardiovascular risk to review with their doctor. These panels bundle the advanced cardiovascular tests with core metabolic, hormone, and nutrient markers in nine tiers.
Best suited for
- Women whose standard cholesterol results are borderline and who want particle-level detail to discuss with their doctor
- Women with a family history of heart disease seeking a fuller set of markers associated with cardiovascular risk
- Anyone tracking whether diet and exercise changes are moving their lipid, particle, and inflammation numbers
- Women who want cardiovascular, metabolic, and inflammation markers measured together in one draw
What's included
Wellness - Women's Select with Lipoprotein Fractionation
9 tests, 101 biomarkers (blood, urine)
Wellness - Women's Baseline with Lipoprotein Fractionation
13 tests, 108 biomarkers (blood, urine)
Wellness - Women's Essential with Lipoprotein Fractionation
18 tests, 115 biomarkers (blood, urine)
Wellness - Women's Essential Plus with Lipoprotein Fractionation
24 tests, 122 biomarkers
Wellness - Women's Performance with Lipoprotein Fractionation
32 tests, 134 biomarkers
Wellness - Women's Performance Plus with Lipoprotein Fractionation
37 tests, 148 biomarkers
Wellness - Women's Premium with Lipoprotein Fractionation
39 tests, 150 biomarkers
Wellness - Women's Premium Plus with Lipoprotein Fractionation
42 tests, 154 biomarkers
Wellness - Women's Comprehensive with Lipoprotein Fractionation
44 tests, 159 biomarkers
Deep-dive the key markers: Fasting Glucose, HbA1c, Fasting Insulin, LDL-C, HDL-C, Triglycerides, hs-CRP, Vitamin D, Ferritin, Total Testosterone, Estradiol, eGFR, ALT
Key biomarker ranges
Commonly used adult reference ranges for markers this panel measures, labs vary, so always interpret results against your lab's stated ranges and with your doctor.
Commonly used reference ranges place fasting glucose at 70–99 mg/dL; results vary with sleep, stress, and recent illness, and labs differ slightly.
| Zone | Range |
|---|---|
| Low | 50–70 mg/dL |
| Optimal | 70–100 mg/dL |
| Prediabetic range | 100–126 mg/dL |
| Diabetic range | 126–160 mg/dL |
Commonly used reference ranges place HbA1c below 5.7%; conditions affecting red blood cells can skew results, so labs and clinicians interpret in context.
| Zone | Range |
|---|---|
| Optimal | 4–5.7 % |
| Prediabetic range | 5.7–6.5 % |
| Diabetic range | 6.5–10 % |
Commonly used reference ranges accept up to ~25 µIU/mL, but many clinicians view single-digit fasting insulin as the more informative target; assays vary by lab.
| Zone | Range |
|---|---|
| Low | 0–2 µIU/mL |
| Optimal | 2–10 µIU/mL |
| Above optimal | 10–25 µIU/mL |
| High | 25–30 µIU/mL |
The importance of testing
Heart disease is the leading cause of death for women, and nearly half of the people who experience a heart attack had no previously identified risk factors. A standard lipid panel reports total LDL, HDL, and triglycerides, but two people with the same LDL number can carry very different lipoprotein particle profiles. Fractionation measures those particle subclasses, adding resolution to the markers you and your doctor use to discuss cardiovascular risk.
Particles are only part of the picture. These panels also measure hs-CRP and fibrinogen activity, markers associated with inflammation and clotting, plus advanced markers like myeloperoxidase and cystatin C, which add insight into inflammatory processes and kidney function. The ApoE genotype test contributes genetic context that can shape how your doctor interprets your lipid results and how you respond to dietary changes.
Because many cardiovascular risk factors, nutrition, activity, smoking, are modifiable, the most useful approach is trend tracking: test, adjust your habits, and retest to see whether particle counts and inflammatory markers move. Each tier also includes metabolic tests such as insulin and hemoglobin A1c, since blood sugar handling and cardiovascular markers are closely linked. Bring the full picture to your physician rather than reacting to any single value.
Part of our complete guide to Heart Health Lab Tests — browse every panel and biomarker guide in this hub.
Promo code
ULTA2A81Save 20% with code ULTA2A81, current promotion; confirm final pricing on the partner page.
Ready to get your numbers? Order online, visit a nearby draw site, and receive private results to review with your doctor.
Order NowFrequently asked questions
How is lipoprotein fractionation different from a standard cholesterol test?
Lipoprotein fractionation measures the subclasses of cholesterol-carrying particles, while a standard lipid panel reports only summary values like total LDL, HDL, and triglycerides. Because particle profiles can differ even when LDL numbers match, fractionation gives your doctor additional markers associated with cardiovascular risk to weigh alongside your history.
Do I need a doctor's order to get lipoprotein fractionation testing?
No doctor's visit is required, these panels can be ordered online, with results delivered privately to your secure account. Choose a tier, complete checkout, and have your sample collected at a local draw location, then bring the results to your own physician for interpretation.
What other heart-related markers do these panels measure?
Beyond particle subclasses, the panels measure hs-CRP and fibrinogen activity, inflammation and clotting markers, and, in higher tiers, advanced markers such as myeloperoxidase, cystatin C, and the ApoE genotype. Metabolic markers like insulin and hemoglobin A1c are included as well, since blood sugar handling is closely linked to cardiovascular health.
Can this testing tell me if I will have a heart attack?
No, no blood test can predict or confirm a heart attack, and this panel is not intended to confirm any condition. It measures markers associated with cardiovascular risk so that you and your doctor can decide together whether lifestyle changes or further evaluation make sense.
Is this testing available in every US state?
No, direct-to-consumer lab testing is restricted or prohibited in New York, New Jersey, and Rhode Island, so residents of those states may be blocked at the partner's checkout. Residents of other states can typically order online and schedule a draw at a nearby location.
References
- [1] Hidden Risks behind Normal Fasting Glucose: Is It Significant? — Diabetes & Metabolism Journal (Korean Diabetes Association, via PMC)
- [2] Good to Know: Factors Affecting Blood Glucose — Clinical Diabetes, American Diabetes Association (via PMC)
- [3] Insulin Resistance & Prediabetes — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- [4] Interpreting A1C: Principles of the A1C Assay — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- [5] Interpreting A1C: Diabetes and Hemoglobin Variants — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- [6] The A1C Test & Diabetes — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- [7] What Is Diabetes? — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- [8] Surrogate markers of insulin resistance: A review — World Journal of Diabetes (via PMC)
- [9] Insulin Assay Standardization: Leading to Measures of Insulin Sensitivity and Secretion for Practical Clinical Care — Diabetes Care, American Diabetes Association (via PMC)
- [10] LDL: The 'Bad' Cholesterol — MedlinePlus (National Library of Medicine, NIH)
- [11] Low-density lipoproteins cause atherosclerotic cardiovascular disease: A consensus statement from the European Atherosclerosis Society Consensus Panel — European Heart Journal
- [12] Familial Hypercholesterolemia — GeneReviews, NCBI Bookshelf (NIH)
- [13] Hypercholesterolemia — StatPearls, NCBI Bookshelf (NIH)
- [14] Low HDL Cholesterol — StatPearls, NCBI Bookshelf (NIH)
- [15] HPS2-THRIVE, AIM-HIGH and dal-OUTCOMES: HDL-cholesterol under attack — Global Cardiology Science & Practice
- [16] Metabolic syndrome — MedlinePlus (National Library of Medicine, NIH)
- [17] Cholesterol Levels: What You Need to Know — MedlinePlus (National Library of Medicine, NIH)
- [18] Triglycerides — MedlinePlus (National Library of Medicine, NIH)
- [19] Hypertriglyceridemia — StatPearls, NCBI Bookshelf (NIH/NLM)
- [20] High Blood Triglycerides — National Heart, Lung, and Blood Institute (NIH)
- [21] C-Reactive Protein (CRP) Test — MedlinePlus (National Library of Medicine, NIH)
- [22] Assessing Cardiovascular Risk with C-Reactive Protein — Johns Hopkins Medicine
- [23] C-Reactive Protein: Clinical Relevance and Interpretation — StatPearls, NCBI Bookshelf (NIH/NLM)
- [24] Vitamin D - Health Professional Fact Sheet — NIH Office of Dietary Supplements
- [25] Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline — Endocrine Society (Journal of Clinical Endocrinology & Metabolism)
- [26] Vitamin D - Health Professional Fact Sheet — NIH Office of Dietary Supplements
- [27] Iron-Deficiency Anemia — StatPearls, NCBI Bookshelf (NIH)
- [28] Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions — International Journal of Chronic Diseases
- [29] Diagnosis of Hemochromatosis — NIDDK (NIH)
- [30] Dose–response relationship of serum ferritin and dietary iron intake with metabolic syndrome and non-alcoholic fatty liver disease incidence: a systematic review and meta-analysis — Frontiers in Nutrition
- [31] Testosterone and Health Outcomes — Institute of Medicine / National Academies Press (NCBI Bookshelf, NIH)
- [32] Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy Men — JAMA (Journal of the American Medical Association)
- [33] Testosterone Levels Test — MedlinePlus (National Library of Medicine, NIH)
- [34] Evaluation and Management of Testosterone Deficiency (2024) — American Urological Association
- [35] The Normal Menstrual Cycle and the Control of Ovulation — Endotext, NCBI Bookshelf (NIH)
- [36] Estradiol — StatPearls, NCBI Bookshelf (NIH)
- [37] Hot Flashes: What Can I Do? — National Institute on Aging (NIH)
- [38] The Female Athlete Triad/Relative Energy Deficiency in Sports (RED-S) — Revista Brasileira de Ginecologia e Obstetrícia
- [39] Physiology, Glomerular Filtration Rate — StatPearls, NCBI Bookshelf (NIH)
- [40] Stages of Chronic Kidney Disease (CKD) — National Kidney Foundation
- [41] What Is Chronic Kidney Disease in Adults? — NIDDK (NIH)
- [42] Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review — Nutrients
- [43] Estimated GFR (eGFR) Test: Kidney Function Levels, Stages, and What to Do Next — National Kidney Foundation
- [44] Alanine Aminotransferase (ALT) Test — StatPearls, NCBI Bookshelf (NIH)
- [45] Definition & Facts of NAFLD & NASH — NIDDK (NIH)
- [46] The Link between NAFLD and Metabolic Syndrome — Diagnostics
- [47] Liver Function Tests — StatPearls, NCBI Bookshelf (NIH)
Reviewed by

Jason August
Founder & Editorial Lead
Jason August is the founder of Metabolic Markers and its parent company, Advancing Development. He has spent his career building and scaling real-world ventures, including as a founding team member at Build-A-Bear Workshop during its growth from startup to global public company, and since then across capital, real estate, adaptive reuse, and hospitality. He founded Metabolic Markers to make blood-biomarker testing easier to understand and access, and oversees the site’s content and editorial accuracy. Jason is not a medical professional; all content on this site is educational, reviewed for accuracy, and never a substitute for advice from a licensed physician.
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